发明名称 |
Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof |
摘要 |
PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.
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申请公布号 |
US2010197927(A1) |
申请公布日期 |
2010.08.05 |
申请号 |
US20080530281 |
申请日期 |
2008.02.26 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES |
发明人 |
NAN FAJUN;LI JIA;WEI YI;ZHANG WEI;LI JINGYA;SHI LEI |
分类号 |
C07D277/30;C07D417/12 |
主分类号 |
C07D277/30 |
代理机构 |
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地址 |
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