BIS(STYRYL)PYRIMIDINE AND BIS(STYRYL)BENZENE DERIVATIVE, PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD THEREOF, AND PREVENTIVE OR THERAPEUTIC MEDICINAL COMPOSITION FOR beta AMYLOID-ACCUMULATION-RELATED DISEASE COMPRISING THE SAME AS EFFECTIVE INGREDIENT

摘要

PROBLEM TO BE SOLVED: To provide a new bis(styryl)pyrimidine derivative compound and a new bis(styryl)benzene derivative compound, and a pharmacologically acceptable salt thereof. SOLUTION: The bis(styryl)pyrimidine derivative and the bis(styryl)benzene derivative are represented by chemical formula 1. A pharmacologically acceptable salt thereof, a production method thereof, and a preventive or therapeutic medicinal composition for aβamyloid-accumulation-related disease comprising the same as an effective ingredient are also provided. The derivative compound of chemical formula 1 inhibitsβamyloid-accumulation to decrease the toxicity of theβamyloid to exhibit effects for improving deterioration in learning abilities and memory appearing in theβamyloid-accumulation-related disease. COPYRIGHT: (C)2010,JPO&INPIT