HIV REPLICATION INHIBITOR, AND USE THEREOF

摘要

Disclosed is a human immunodeficiency virus (HIV) replication inhibitor comprising an antibody capable of recognizing human CD4. Specifically disclosed is an HIV replication inhibitor comprising the following antibody (1) as an active ingredient: (1) an antibody capable of recognizing human CD4, which comprises the amino acid sequence depicted in SEQ ID NO:2 shown in the Sequence Listing or an amino acid sequence having at least one mutation selected from a group consisting of deletion, substitution, inversion, addition and insertion of one to several amino acid residues in the amino acid sequence depicted in SEQ ID NO:2 shown in the Sequence Listing as an amino acid sequence for a heavy chain variable region, and also comprises the amino acid sequence depicted in SEQ ID NO:4 shown in the Sequence Listing or an amino acid sequence having at least one mutation selected from a group consisting of deletion, substitution, inversion, addition and insertion of one to several amino acid residues in the amino acid sequence depicted in SEQ ID NO:4 shown in the Sequence Listing as an amino acid sequence for a light chain variable region.