发明名称 |
SITE-SPECIFIC N-TERMINAL MODIFICATIONS OF PROTEINS AND CONJUGATE FORMATION |
摘要 |
Site-specific modifications of proteins at their N-termini are provided. In particular, a chemical modification of proteins at their N-termini via a transamination reaction to form homogeneous adducts such as, the corresponding oxime derivatives is provided. Methods of making and using the adducts in radio-labelling, molecular imaging applications, and treatment of disorders such as cancer, Crohn's disease, arthritis, atherothrombosis and plaque rupture are also provided. |
申请公布号 |
WO2010040147(A9) |
申请公布日期 |
2010.08.05 |
申请号 |
WO2009US59597 |
申请日期 |
2009.10.05 |
申请人 |
ADVANCED PROTEOME THERAPEUTICS, INC.;YU, PENG;KRANTZ, ALEXANDER |
发明人 |
YU, PENG;KRANTZ, ALEXANDER |
分类号 |
C07K1/107;A61K38/00;C07K14/00 |
主分类号 |
C07K1/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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