USE OF URINARY NGAL TO DIAGNOSE AND MONITOR HIV-ASSOCIATED NEPHROPATHY (HIVAN)

摘要

The present invention is directed to methods for diagnosis of HIVAN, and to methods for distinguishing between HIVAN and other kidney diseases, based on the presence in a bodily fluid, such as urine, of a level of NGAL protein that exceeds a threshold level. The present invention is also directed to methods for diagnosis of HIVAN based on the differential expression of NGAL and one or more other markers, such as KIM-I, and to methods of diagnosis based on a specific localization of NGAL in microcysts or microcystic tubules of the kidney.