发明名称 |
ANTISENSE MODULATION OF ACYL COA CHOLESTEROL ACYLTRANSFERASE-2 EXPRESSION |
摘要 |
Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
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申请公布号 |
US2010197764(A1) |
申请公布日期 |
2010.08.05 |
申请号 |
US20090650288 |
申请日期 |
2009.12.30 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
CROOKE ROSANNE M.;TARBET KRISTINA LEMONIDIS;GRAHAM MARK J. |
分类号 |
A61K31/7088;A61K38/00;A61P3/00;A61P9/00;A61P9/10;C07H21/04;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
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主权项 |
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地址 |
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