发明名称 |
DELIVERY OF NUCLEIC ACIDS USING CELL-PENETRATING PEPTIDES |
摘要 |
<p>The present invention is based on the innovative concept of conjugating a cell- penetrating peptide (CPP), including a protein transduction domain, to a nucleic acid molecule to provide a nucleic acid-protein conjugate exhibiting enhanced cellular uptake. Accordingly, the invention provides a method of producing a cell permeable nucleic acid molecule conjugate nucleic acid including a nucleic acid conjugated with a homeodomain of an antennapedia homeotic transcription factor protein (Antp), or functional fragment thereof. The invention further provides compositions and methods treating a subject using the conjugates produced by the method described herein.</p> |
申请公布号 |
WO2010086597(A1) |
申请公布日期 |
2010.08.05 |
申请号 |
WO2010GB00126 |
申请日期 |
2010.01.27 |
申请人 |
TROJAN TECHNOLOGIES LTD.;EPENETOS, AGAMEMNON;KOUSPAROU, CHRISTINA |
发明人 |
EPENETOS, AGAMEMNON;KOUSPAROU, CHRISTINA |
分类号 |
C12N15/113;A61K47/48 |
主分类号 |
C12N15/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|