| 摘要 |
PROBLEM TO BE SOLVED: To provide a gene-detecting method or the like for obtaining one element for judging the hereditary risk of cerebral infarction. SOLUTION: The method for detecting the hereditary risk of cerebral infarction includes determining rs1671021 polymorphism of LLGL2, rs9615362 polymorphism of CELSR1 and rs753307 polymorphism of RUVBL2 associated with cerebral infarction, discovered by carrying out genome-wide association study (GWAS) from about 520,000 genetic polymorphisms associated with a group of 6,341 Japanese people. Three tag SNPs and one nonsynonymous SNP among the base sequences of linkage disequilibrium blocks including the polymorphisms are associated with cerebral infarction, and especially, rs6007897 (A→G, Thr2268Ala) of CELSR1 and rs4044210 (A→G, Ile2107Val) of CELSR1 are important SNPs accompanying amino acid substitution. COPYRIGHT: (C)2010,JPO&INPIT |
