发明名称 |
BINARY EPITOPE ANTIBODIES AND B CELL SUPERANTIGEN IMMUNE STIMULANTS |
摘要 |
Provided herein are dual epitope polypeptides and electrophilic analogs thereof having a superantigenic epitope and at least one other epitope effective to induce the production of antibodies with binary specificity for the epitopes on a polypeptide antigen. Also, provided are electrophilic analogs of polyclonal B cell stimulants or lipids, polysaccharides and lipopolysaccharides or nucleotides. In addition, provided herein are methods for increasing production of binary epitope specific antibodies recognizing B cell polypeptide antigens, for stimulating production of antibodies using one or more of the polypeptides or electrophilic analogs and for isolating binary epitope specific antibodies or fragments thereof. Further provided are the antibodies so produced and methods of treating HIV using the same. |
申请公布号 |
EP2091973(A4) |
申请公布日期 |
2010.08.04 |
申请号 |
EP20070874124 |
申请日期 |
2007.11.09 |
申请人 |
PAUL, SUDHIR;NISHIYAMA, YASUHIRO;PLANQUE, STEPHANIE |
发明人 |
PAUL, SUDHIR;NISHIYAMA, YASUHIRO;PLANQUE, STEPHANIE |
分类号 |
C07K16/10;A61K38/16;C07K16/08 |
主分类号 |
C07K16/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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