发明名称 |
METHOD FOR DETECTION OR TREATMENT OF GRAFT VERSUS HOST DISEASE |
摘要 |
Disclosed is a method of diagnosing graft-versus-host disease, comprising measuring the level of CCL8 protein in a sample obtained from a subject as an indicator for the diagnosis or course of graft-versus-host disease. Also a diagnostic reagent for graft-versus-host disease comprising an anti-CCL8 antibody is disclosed. The method of the present invention enables diagnosis of the onset of graft-versus-host disease and monitoring of the progress, in particular, differential diagnosis between graft-versus-host disease and an infectious disease. The present invention also provides a method for treating graft-versus-host disease utilizing the anti-CCL8 antibody. |
申请公布号 |
EP2163896(A4) |
申请公布日期 |
2010.08.04 |
申请号 |
EP20080764208 |
申请日期 |
2008.06.23 |
申请人 |
SAPPORO MEDICAL UNIVERSITY;IMMUNO-BIOLOGICAL LABORATORIES CO., LTD. |
发明人 |
HORI, TSUKASA;KOKAI, YASUO;NAISHIRO, YASUYOSHI;TSUTSUMI, HIROYUKI;IMAI, KOHZOH |
分类号 |
G01N33/53;A61K39/395;A61P37/06;G01N27/62;G01N30/72;G01N30/88;G01N33/15;G01N33/50;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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