UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR EPITOPE, MONOCLONAL ANTIBODIES DERIVED THEREFROM AND METHODS OF USE THEREOF

摘要

The present invention relates to antibodies, and antigen-binding fragments thereof, specific for urokinase-type plasminogen activator receptor (uPAR) and uses thereof for the treatment or prevention of cancer. In particular, the antibodies of the invention are specific for a particular epitope on uPAR. These antibodies interfere with uPAR signaling. Such antibodies are used in diagnostic and therapeutic methods, particularly against cancer.