发明名称 |
STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS |
摘要 |
The present invention provides liquid formulations of SYNAGIS ® or an antigen binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS ® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS ® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides methods of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention. |
申请公布号 |
EP1531862(B1) |
申请公布日期 |
2010.08.04 |
申请号 |
EP20030739146 |
申请日期 |
2003.06.16 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
OLIVER, CYNTHIA N.;SHANE, ERICA;ISSAACS, BENJAMIN, S.;ALLAN, CHRISTIAN, B.;CHANG, STEPHEN |
分类号 |
A61K39/385;A61K9/00;A61K39/42;A61K47/18;A61K47/26;C07K16/00;C07K16/10 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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