发明名称 |
Prenyl-electrostatic switch, and methods of use |
摘要 |
The present invention relates to a method of identifying compounds as candidate drugs for treatment of cancer by providing a cell expressing a GTPase protein that is regulated by a prenyl-electrostatic switch, contacting the cell with compounds to be evaluated, and selecting compounds able to regulate charge at the prenyl-electrostatic switch in the GTPase protein as candidate drugs for treatment of cancer. Also disclosed are methods of treating cancer in a patient. An isolated antibody which binds to a phosphorylated prenyl-electrostatic switch on a K-Ras4B protein is also disclosed, as is a kit for detecting phosphorylation of a prenyl-electrostatic switch in a K-Ras4B protein which includes a labeled antibody and a device to detect the label. Also disclosed is a method of detecting phosphorylation of a prenyl-electrostatic switch on a K-Ras4B protein in a biological sample.
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申请公布号 |
US7767417(B2) |
申请公布日期 |
2010.08.03 |
申请号 |
US20050109262 |
申请日期 |
2005.04.19 |
申请人 |
NEW YORK UNIVERSITY |
发明人 |
PHILIPS MARK R.;BIVONA TREVER G. |
分类号 |
C12P21/06;A61K31/497;A61K38/17;A61K38/48;A61K39/395;C07H21/04;C07K14/32;G01N33/574 |
主分类号 |
C12P21/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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