Selected tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain

摘要

Disclosed is a tetracyclic tetrahydrofuran derivative as represented by the general Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof, and a quaternary ammonium salt thereof, wherein: R1 is halo; R2 is hydrogen; X is CH2; and A is piperazine radical which is substituted in the 4-position by R5, wherein R5 is as defined herein. Also disclosed is the use of a compound as defined above for the manufacture of a medicament for the treatment of conditions, either prophylactic or therapeutic or both, mediated through the 5-HT2 and/or D2 receptor (conditions such as central nervous system disorders, anxiety, bipolar disorders, sleep- and sexual disorders, psychosis, borderline psychosis, schizophrenia, migraine, personality disorders or obsessive-compulsive disorders, social phobias or panic attacks, organic mental disorders, mental disorders in children, aggression, memory disorders and attitude disorders in older people, addiction, obesity, bulimia and other similar disorders).