摘要 |
Disclosed are compounds such as oxazolo[4,5-b]pyridine-2-one derivatives as represented by the general formula I, where: X identically or differently =C(-R)- or =N-, where at least one and at most two =C(-R-)- is replaced by =N-; Y is -O- or -S-; R1 is alkyl, alkylene-aryl, alkylene-heteroaryl, alkylene-cycloalkyl or bicycle, where aryl, heteroaryl, cycloalkyl or bicycle may be substituted; R2 is hydrogen, alkyl; or R1 and R2 form together with the nitrogen atom bearing them a monocyclic, saturated or partially unsaturated 4- to 7-membered ring system or a bicyclic saturated or partially unsaturated 8- to 14-membered ring system, of which individual members of the ring systems may be replaced by one to three atoms or atomic groups from the series -CHR4-, -CR4R5-, -(C=R4)-, -NR6-, -C(=O)-, -O-, -S-, -SO-, -SO2-; and wherein the other substituents are as defined herein. Also disclosed is the use of a compound as defined above for producing a medicament for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders, disorders in which insulin resistance Is involved, diabetes mellitus, dyslipidemias, conditions associated with the metabolic syndrome, conditions associated with reduced HDL level and atherosclerotic disorders.
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