摘要 |
Disclosed is a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide toluene sulphonic acid salt of the formula (I) which comprises, in a first step, reacting the compound of the formula (V) with 4-chloro-3-trifluoromethylphenyl isocyanate in a nonchlorinated organic solvent, inert toward isocyanates, by initially charging the compound of the formula (V) at a temperature of from 20°C to 60°C and admixing with 4-chloro-3-trifluoromethylphenyl isocyanate in such a way that the reaction temperature does not exceed 70 degrees C to give the compound of the formula (II) and, in a second step, admixing the compound of the formula (II) with p-toluenesulfonic acid in a polar solvent at a reaction temperature of from 40 degrees C up to the reflux temperature of the solvent used.
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申请人 |
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT |
发明人 |
LOGERS, MICHAEL;MATTHAUS, MIKE;GEHRING, REINHOLD;KUHN, OLIVER;MOHRS, KLAUS;MULLER-GLIEMANN, MATTHIAS;STIEHL, JURGEN;BERWE, MATHIAS;LENZ, JANA;HEILMANN, WERNER |