Benzimidazole non-aqueous compositions

摘要

An oral veterinary composition is disclosed, which comprises: a benzimidazole compound; a macrocyclic lactone; one or more surfactants in an amount between 30% w/v and 60% w/v; a pharmaceutically acceptable oil in an amount of about 25-65% w/v; and a water-miscible solvent, wherein the composition is a non-aqueous solution. The composition is suitably adapted for administration as a gavage or a drench to an animal is selected from swine; cattle; horses and sheep. Preferable benzimidazole compound is thiabendazole; cambendazole; parbendazole; mebendazole; fenbendazole; oxfendazole; oxibendazole; albendazole; albendazole sulfoxide; thiophanate; febantel; netobimin or triclabendazole. Preferable macrocyclic lactone is milbemycin D; avermectin; ivermectin; abamectin; doramectin or moxidectin. Preferable watermiscible solvent is an alkylene glycol; a polyalkylene glycol or an alcohol or a mixture thereof. Preferable oil is propylene glycol dicaprylate/dicaprate. Surfactants suitable for use in the composition include non-ionic surfactants such as sucrose monolaurate, sorbitan monooleate or polysorbate 80; polyethylene glycol 660 hydroxystearate; polyoxyl 35 castor oil; PEG-60 hydrogenated castor oil or the like.