Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

摘要

Disclosed is a cell-binding agent maytansinoid conjugate having at least one maytansinoid linked to a cell-binding agent via a non-cleavable linker, wherein the cell-binding agent is an antibody, a single chain antibody or an antibody fragment that specifically bind to a target cell, wherein the antibody, single chain antibody or antibody fragment comprises a human constant region.