Novel 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1

摘要

The disclosure relates to 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula (I) and their pharmaceutically acceptable salts, wherein R2 represents a C1-C8 alkyl, a C1-C8 alkyloxy group or a halogen atom, R13 represents a hydrogen atom or a methyl group, R17 represents a hydrogen atom or a fluorine atom, and the dotted lines in the B- and D- ring of the steroid molecule can be additional double bonds. The disclosure also relates to the pharmaceutically acceptable salts of said compounds, to the production thereof, and to the use of the same as medicaments for the prophylaxis and treatment of oestrogen-dependent diseases that can be influenced by the inhibition of 17beta-hydroxysteroid dehydrogenase type 1.