REGULATION OF EXPRESSION OF PI3KBETA PROTEIN IN TUMORS

摘要

The present invention concerns the use of PI3K&bgr; protein and/or encoding gene for the screening for substances useful in the treatment of cancers, preferably breast cancers. The present invention also concerns a method for the diagnosis of malignant cell growth comprising the measuring the expression of PI3K&bgr; gene. The invention concerns also non-human transgenic animals as model study for human pathologies, preferably breast cancer, being transgenic for having altered PI3K&bgr; and Neu-T expression.