发明名称 |
Tubulin Isotype Screening in Cancer Therapy Using Halichondrin B Analogs |
摘要 |
Chemotherapeutic agents that interfere with microtubule assembly or disassembly in the cell are potent inhibitors of cell replication. Examples of such agents include halichondrin B analogs. It has been shown that the susceptibility of certain cancers to analogs of halichondrin B correlates with the expression of particular tubulin isotypes or other microtubule-associated proteins such as MAP-4 and stathmin. Correlations such as these may be used in identifying patients suitable for treatment using a particular chemotherapeutic agent. Such a system avoids treating patients with cytotoxic compounds where there is a minimal or no effect on the cancer. The invention also provides a system of establishing these correlations for different compounds and cancer types. The system will be particularly useful in establishing correlations between anti-microtubule agents and cancers such as lung, breast, and ovarian cancer. Kits and reagents useful in practicing the invention are also provided.
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申请公布号 |
US2010190843(A1) |
申请公布日期 |
2010.07.29 |
申请号 |
US20090534277 |
申请日期 |
2009.08.03 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
AGOULNIK SERGEI;KUZNETSOV GALINA;LITTLEFIELD BRUCE A. |
分类号 |
A61K31/335;A61P35/00;C07H21/04;C12Q1/02;C12Q1/68;C40B30/04;G01N33/48;G01N33/53;G01N33/68 |
主分类号 |
A61K31/335 |
代理机构 |
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