发明名称 WATER-SOLUBLE BINUCLEAR NITROSYL IRON COMPLEXES WITH NATURAL ALIPHATIC THIOLYLS POSSESSING CYTOTOXIC, APOPTOTIC AND NO-DONOR ACTIVITY
摘要 The present invention relates to water-soluble binuclear cationic nitrosyl iron complexes with natural aliphatic thiolyls of general formula [Fe2(SR)2(NO)4]SO4, wherein R is sulfur-containing aliphatic ligands of natural origin, preferably, cystamine or penicillamine, to a method for the preparation thereof, to use thereof as an anticancer agent, to an apoptosis inducer, to a pharmaceutical composition comprising said complexes in an effective amount, and to a kit useful for the treatment of cancer diseases.
申请公布号 US2010190850(A1) 申请公布日期 2010.07.29
申请号 US20080602867 申请日期 2008.06.02
申请人 INSTITUTE OF PROBLEMS OF CHEMICAL PHYSICS RAS (IPCP RAS) 发明人 SANINA NATALIA ALEXEEVNA;LYSENKO KONSTANTIN ALEXANDROVICH;ZHUKOVA OLGA STEPANOVNA;RUDNEVA TATYANA NIKOLAEVNA;EMELIANOVA NINA SERGEEVNA;ALDOSHIN SERGEI MIKHAILOVICH
分类号 A61K31/295;A61P35/00;C07F15/02 主分类号 A61K31/295
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