REVERSE-MICELLAR DELIVERY SYSTEM FOR CONTROLLED TRANSPORTATION AND ENHANCED ABSORPTION OF AGENT

摘要

PROBLEM TO BE SOLVED: To provide a delivery system of transmembrane transportation for the controlled sustained release of an agent of interest and to provide a composition and a method for preparing the delivery system. SOLUTION: The delivery system is a reverse-micellar delivery system for enhancing the absorption an agent of interest across biological membranes such as gastrointestinal tracts of mammals, wherein the reverse-micellar includes at least one ionic amphipathic compound and at least one polar active agent ionizable in aqueous medium or physiological media. The delivery system facilitates the transportation of the agent across gastrointestinal tracts or other membranes and enhances the in-vivo release and availability of the agent of interest within a fluid environment. COPYRIGHT: (C)2010,JPO&INPIT