ORALLY ADMINISTERABLE VACCINE FOR YERSINIA PESTIS

摘要

Disclosed herein is the successful expression of the plague Fl-V fusion antigen in chloroplasts. Parenteral and/or oral administration of chloroplast produced antigens effectively elicit protective immune responses in vivo. Disclosed herein is the first report of a plant-derived oral vaccine that protected animals from live Y. pestis challenge, bringing the likelihood of lower-cost vaccines closer to reality.