MUTANT PATHOGENIC BACTERIAL AND LIVE ATTENUATED VACCINE COMPOSITIONS

摘要

The invention relates to a mutant pathogenic bacterium, preferably a mutant intracellular pathogenic bacterium, that is incapable of expressing one or more metabolic genes; preferably the mutant pathogenic bacterium is attenuated. A mutant pathogenic bacterium of the invention may be incapable of expressing two or more metabolic genes, which encode proteins involved in the same or in different metabolic pathways, such as glycolysis and sugar transport. The invention also relates to vaccines comprising a live attenuated mutant pathogenic bacterium of the invention, methods for their production and their use for the protection of humans or animals against infection with a pathogenic bacterium or against the pathogenic effects of infection.