| 摘要 |
The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: HoN,.Xi,xi H9N,.X1.,?{ xz ^z X "x2 ^z R 1 / R 1 K COOH COOH IA IB or a pharmaceutically acceptable salt thereof, compositions containing these compounds, and methods of their use for the treatment and diagnosis of conditions characterized by upregulation of arginase, abnormally high arginase activity, or by abnormally low nitric oxide synthase activity. |
| 申请人 |
THE TRUSTEES OF UNIVERSITY OF PENNSYLVANIA;ARGINETIX, INC.;CHRISTIANSON, DAVID, W.;TOMCZUK, BRUCE, EDWARD;POTTORF, RICHARD, SCOTT;COLASANTI, ANDREW, VARGHA;OLSON, GARY, LEE |
发明人 |
CHRISTIANSON, DAVID, W.;TOMCZUK, BRUCE, EDWARD;POTTORF, RICHARD, SCOTT;COLASANTI, ANDREW, VARGHA;OLSON, GARY, LEE |
