发明名称 |
PYRAZOLE-I, 2, 4 -OXAD IAZOLE DERIVATIVES AS S.PHING0SINE-1-PH0SPHATE AGONISTS |
摘要 |
<p>Disclosed are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: n is zero or an integer selected from 1 through 4; R1 is cycloalkyl, aryl, heteroaryl, or heterocyclyl, each optionally substituted with one to five substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, benzyl, OR4, and/or halogen; and R2, R3, R4, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.</p> |
申请公布号 |
WO2010085584(A1) |
申请公布日期 |
2010.07.29 |
申请号 |
WO2010US21696 |
申请日期 |
2010.01.22 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;DYCKMAN, ALARIC, J.;PITTS, WILLIAM, J.;WATTERSON, SCOTT, HUNTER |
发明人 |
DYCKMAN, ALARIC, J.;PITTS, WILLIAM, J.;WATTERSON, SCOTT, HUNTER |
分类号 |
C07D413/14;A61K31/4245;A61P37/00 |
主分类号 |
C07D413/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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