Stable micronized candesartan cilexetil and methods for preparing thereof

摘要

The invention encompasses stable candesartan cilexetil of fine particle size, wherein desethyl-candesartan (desethyl-CNS) within the stable candesartan cilexetil does not increase to more than about 0.1%w/w by HPLC relative to the initial amount of candesartan cilexetil, when the stable candesartan cilexetil is maintained at a temperature of about 55°C for at least 2 weeks, methods of making the same and pharmaceutical compositions thereof.