Synthesis of 1±-fluoro-25-hydroxy-16-23E-diene-26,27-bishomo-20-EPI-cholecalciferol

摘要

The invention provides a method of producing 20-methyl vitamin D3 compounds of formula (I). The method includes allylic and olefin oxidation, de-carbonylation, carbonyl reduction, fluoride substitution, epoxide deoxygenation, and Wittig-type couplings.