SDF-1-BASED GLYCOSAMINOGLYCAN ANTAGONISTS AND METHODS OF USING SAME

摘要

The present invention relates to novel mutants of human stromal cell-derived factor-1 which exhibit increased glycosaminoglycan (GAG) binding affinity and inhibited or down-regulated GPCR activity compared to wild type SDF-1, methods for producing these mutants and to their use for preparing medicaments for the treatment of cancer.