发明名称 |
UNSATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS |
摘要 |
<p>The present invention relates to compounds of formula (I); and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smo antagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.</p> |
申请公布号 |
WO2010082044(A1) |
申请公布日期 |
2010.07.22 |
申请号 |
WO2010GB50034 |
申请日期 |
2010.01.12 |
申请人 |
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.;BRANCA, DANILA;DESSOLE, GABRIELLA;FERRIGNO, FEDERICA;JONES, PHILIP;KINZEL, OLAF;MURAGLIA, ESTER |
发明人 |
BRANCA, DANILA;DESSOLE, GABRIELLA;FERRIGNO, FEDERICA;JONES, PHILIP;KINZEL, OLAF;MURAGLIA, ESTER |
分类号 |
C07D209/08;A61K31/416;A61P35/00;C07D231/56;C07D401/04;C07D403/04;C07D403/10;C07D471/04;C07D495/04 |
主分类号 |
C07D209/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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