EPOTHILONE-CONTAINING COMBINATIONAL PREPARATION AND USE THEREOF AS PHARMACEUTICAL

摘要

PROBLEM TO BE SOLVED: To provide a combinational preparation useful for delaying the progression of proliferative diseases or treating such diseases. Ž

SOLUTION: The combinational preparation includes: (a) a bisphosphonate, platinum compound or vascular-inactivating compound and (b) an epothilone derivative represented by formula (I)(wherein, A is O or NRN, wherein RNis H or lower alkyl, and R is H or lower alkyl; and Z is O or single bond). Ž

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