HUMAN PHOSPHOLIPASE A2 EPSILON

摘要

A novel function phospholipase A2, referred to herein as calcium-independent phospholipase A2&egr; (iPLA2&egr;) having SEQ ID NO: 1 and SEQ ID NO: 2, and nucleic acid sequences (SEQ ID NO: 3 and SEQ ID NO: 4) encoding and expressing iPLA2&egr; is disclosed. This novel enzyme has been isolated and characterized and is involved in the catalysis and hydrolysis of lipids cycling in a living cell biosystem. In an embodiment, the iPLA2&egr; polypeptide is encoded and expressed by an isolated nucleic acid molecule comprising a set of iPLA2&egr; polynucleotides. In one aspect, an isolated and characterized gene comprises a polynucleotide having a sequence shown in SEQ ID NO: 3 and SEQ ID NO: 4.