发明名称 |
NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES |
摘要 |
The present invention relates to a novel water based process for the preparation of substituted diphenylmethyl piperazines of Formula (I) and pharmaceutically acceptable salts: wherein X1 and X2 represent independently a hydrogen, a halogen, a straight or branched chain lower alkyl, alkoxy or a hydroxyl radical and R is selected from groups such as acyl, alkyl, alkenyl, aralalkyl, aralalkenyl aralkyl, and aralalkenyl or aralkenyl hydroxyalkyl, aryloxyalkyl, alkoxyalkyl, aminoalkyl or its derivative comprising, reacting a compound of Formula (II), with a compound of formula R-X where R is as defined above and X is suitable leaving group which includes halides, but not limiting use of other leaving groups such as tosylate, mesylate and activated acid groups such as acyl halide, anhydrides, mixed anhydrides etc.using water as a solvent, in presence of a catalyst and a base, at 25-100 °C; Formula (II). |
申请公布号 |
WO2010046908(A3) |
申请公布日期 |
2010.07.22 |
申请号 |
WO2009IN00509 |
申请日期 |
2009.09.16 |
申请人 |
CALYX CHEMICALS AND PHARMACEUTICALS PVT. LTD.;LAL, BANSI;LAHIRI, SANJOY;BAPAT CHINTAMANI, PRABHAKAR;KULKARNI RAHUL, SURESH;MULLA, DILAWAR, KASAM;HAWALDAR, ASHISH, YASIN |
发明人 |
LAL, BANSI;LAHIRI, SANJOY;BAPAT CHINTAMANI, PRABHAKAR;KULKARNI RAHUL, SURESH;MULLA, DILAWAR, KASAM;HAWALDAR, ASHISH, YASIN |
分类号 |
C07D295/088;C07D295/027;C07D295/073 |
主分类号 |
C07D295/088 |
代理机构 |
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