发明名称 |
METHODS OF DETERMINING PATIENT RESPONSE BY MEASUREMENT OF HER-2 EXPRESSION |
摘要 |
Methods are provided for determining or otherwise assessing the response of a patient to treatment, in particular, to cancer treatment. The methods include the analysis of samples for the presence or the absence of HER2 markers alone or in conjunction with other biomarkers, such as HER3 markers. In certain examples, the probable time to progression can be determined by first determining HER2 positive patients and then further stratifying by using the presence or the absence of a second biomarker (e.g, HER3 markers). In addition, the data can be used to track a patient's response to a treatment regimen, assessing the expected success of treating a patient using a particular regiment, determining the effects of a treatment regiment or for categorizing a patient in order to create a homogenous group for a clinical trial. |
申请公布号 |
CA2749817(A1) |
申请公布日期 |
2010.07.22 |
申请号 |
CA20102749817 |
申请日期 |
2010.01.15 |
申请人 |
LABORATORY CORPORATION OF AMERICA HOLDINGS |
发明人 |
BATES, MICHAEL;COOK, JENNIFER W.;DIEDRICH, GUNDO;GOODMAN, LAURIE;MUKHERJEE, ALI;PARRY, GORDON;SPERINDE, JEFF;WILLIAMS, STEPHEN JOHN |
分类号 |
G01N33/48;G01N33/574;G01N33/68 |
主分类号 |
G01N33/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|