| 摘要 |
This invention provides compositions, methods and systems to modulate the lipid content and membrane characteristics of cells and virions. Growth of host cells on media containing particular amounts, classes and/or combinations of lipid supplements can influence the lipid content of the cell and viruses grown on the cell. Lipids, such as cholesterol esters, sphingomyelin, glycolipids, containing C16:0, C18:0, C18: 1n9 and/or C18:2n6 fatty acids, can influence cell permissivity for virus infection, virus yield, virus immunogenicity and/or membrane phase transition temperatures.
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