发明名称 |
METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING |
摘要 |
The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
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申请公布号 |
US2010184826(A1) |
申请公布日期 |
2010.07.22 |
申请号 |
US20100729892 |
申请日期 |
2010.03.23 |
申请人 |
UNIVERSITY OF MASSACHUSETTS |
发明人 |
ZAMORE PHILLIP D.;HUTVAGNER GYORGY;SCHWARZ DIANNE;SIMARD MARTIN |
分类号 |
A61K31/713;A61K48/00;A61P31/00;A61P35/00;A61P37/00;C07H21/02;C12N15/11;C12N15/113;C12N15/85;C12Q1/68 |
主分类号 |
A61K31/713 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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