| 摘要 |
The invention provides novel recombinant G&bgr;5 complex proteins, novel methods of identifying compounds that modulate the conformation of G&bgr;5 complex, novel methods of treating disorders, including neurological and metabolic disorders, with modulators of G&bgr;5 complex activity, and a mouse model of obesity, where the expression level of G&bgr;5 complex is reduced by targeted deletion of one allele of a gene encoding a member of the G&bgr;5 complex.
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