METHOD OF INHIBITING PROLIFERATION OF HEPATIC STELLATE CELLS

摘要

There is presently provided a method of inhibiting proliferation of a hepatic stellate cell comprising directly down-regulating the hepatic stellate cell proliferation activity of connexin-43 in the hepatic stellate cell for the treatment of hepatic fibrosis or related disorder. This method primarily involves down regulating connexin-43 with agents such as Snail, siRNAs, anisense RNA and DNA enzymes directed against the connexin-43 transcript. As a result the proliferation of activated hepatic stellate cells is down regulated.