| 发明名称 |
IMIDAZOTHIAZOLE DERIVATIVE HAVING PROLINE RING STRUCTURE |
| 摘要 |
<p>Disclosed is a novel compound which inhibits the interaction between the Mdm2 (murine double minute 2) protein and the p53 protein and has an antitumor activity. Specifically disclosed is an imidazothiazole derivative, which is represented by formula (1) and has various substituents. The imidazothiazole derivative inhibits interaction between the Mdm2 protein and the p53 protein, and has an antitumor activity. (In formula (1), R1, R2, R3, R4, R5, R6, R7, Ar1 and Ar2 are as defined in the description.)</p> |
| 申请公布号 |
WO2010082612(A1) |
申请公布日期 |
2010.07.22 |
| 申请号 |
WO2010JP50372 |
申请日期 |
2010.01.15 |
| 申请人 |
DAIICHI SANKYO COMPANY,LIMITED;UOTO, KOUICHI;SUGIMOTO, YUUICHI;NAITO, HIROYUKI;MIYAZAKI, MASAKI;YOSHIDA, KEISUKE;AONUMA, MASASHI |
发明人 |
UOTO, KOUICHI;SUGIMOTO, YUUICHI;NAITO, HIROYUKI;MIYAZAKI, MASAKI;YOSHIDA, KEISUKE;AONUMA, MASASHI |
| 分类号 |
C07D513/04;A61K31/499;A61P35/00;A61P43/00 |
主分类号 |
C07D513/04 |
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