HETEROCYCLIC DERIVATIVE HAVING INHIBITORY ACTIVITY ON TYPE-I 11 -HYDROXYSTEROID DEHYDROGENASE

摘要

Disclosed is a compound which is useful as an 11²-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula:
its pharmaceutically acceptable salt, or a solvate thereof, wherein X is O or S, a broken line and a wavy line represent the presence or the absence of a bond,
(i) when a broken line represents the presence of a bond, a wavy line represents the absence of a bond,
R 2 and R 3 are each independently hydrogen, halogen, cyano, hydroxy, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like,
(ii) when a broken line represents the absence of a bond, a wavy line represents the presence of a bond,
R 1 and R 4 are each independently hydrogen, halogen or the like,
R 2 and R 3 are each independently hydrogen, halogen, cyano, hydroxy, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like, and
R 5 and R 6 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like.