发明名称 |
ANTIBODIES SPECIFIC FOR THE PROTOFIBRIL FORM OF BETA-AMYLOID PROTEIN |
摘要 |
Isolated antibodies have been characterized which show specific affinity to a repeating conformational epitope of a protofibril form of the human beta-amyloid peptide as compare to low molecular weight forms of beta-amyloid peptide. These isolated antibodies and related pharmaceutically effective compositions may be useful in the therapeutic and/or prophylactic treatment of Alzheimer's disease by effectively blocking the ability of the protofibril form of beta-amyloid peptide to form fibril forms linked with complications associated with Alzheimer's disease. The isolated antibodies of the present invention are also useful in various diagnostic assays and associated kits. |
申请公布号 |
EP2207568(A2) |
申请公布日期 |
2010.07.21 |
申请号 |
EP20080849467 |
申请日期 |
2008.11.14 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
RAVETCH, JEFFREY;FUKUYAMA, HIDEHIRO |
分类号 |
C07K16/18;A61K39/395;A61P25/28;G01N33/53;G01N33/567 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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