| 摘要 |
<p>The present invention relates to canine interleukin 18 and an interleukin 18 production method based on genetic engineering.</p><p>That is to say, it relates to canine interleukin 18 having at least one of the abilities selected from an ability to act on canine leukocytes and induce antiviral active factors and factors which enhance class II MHC expression on canine tumour cells; an ability to promote canine lymphocyte proliferation; an ability to enhance Fas ligand expression on canine lymphocytes and canine tumour cells; an ability to obstruct and destroy canine tumour cells; an ability to bring about a reduction in size of tumours occurring in the bodies of dogs; and an ability to activate canine leukocytes and suppress canine allergies.</p><p>Specifically, it relates to canine interleukin 18 having the amino acid sequence shown in Sequence No: 1 or an amino acid sequence comprising part thereof and a method for its production, and a gene coding for this, that is to say a gene coding for the amino acid sequence shown in Sequence No: 1 or an amino acid sequence comprising part thereof; canine interleukin 1β converting enzyme which has the amino acid sequence shown in Sequence No: 2 or an amino acid sequence comprising part thereof and a gene coding for this, that is to say a gene coding for the amino acid sequence shown in Sequence No: 2 or an amino acid sequence comprising part thereof; and a production method where interleukin 18 is produced by insect cells or larvae.</p> |
