STEREO-SPECIFIC HYDROXYLATION

摘要

The invention relates to a method for the stereospecific hydroxylation of α-amino-S-carboxylic acid derivatives or α-amino-R-sulfonic acid derivatives to form α-amino-&bgr;-hydroxy-S-carboxylic acid- or α-amino-&bgr;-hydroxy-R-sulfonic acid compounds, with the hydroxyl and acid groups being trans-configured and making use of microorganisms exhibiting hydroxylase activity in a production medium to which the S-carboxylic- or R-sulfonic acid derivatives are added and hydroxylated in the microorganism in the presence of oxygen and a cosubstrate using osmotically activated transporting systems of the microorganism and subsequently released actively or passively from the microorganism so as to be obtained from the production medium.