| 摘要 |
This invention relates to vehicles for the percutaneous delivery of at least one pharmaceutically active agent to the epidermis. In particular this invention relates to pharmaceutical compositions directed to the treatment of skin diseases, more particularly those containing salicylic acid. More specifically, a hydroalcoholic vehicle for percutaneous delivery of an active agent to the epidermis, said vehicle comprising lower alcohol, water and wax-surfactant, said wax surfactant being one, or a combination of compounds selected from the group consisting of acyl glutamates, phosphoric acids or salts, acyl isethionates, alkyl ether sulfates, alkyldibenzylmethylammonium salts, heterocyclic ammonium salts, tetraalkylammonium salts, ethoxylated carboxylic acids, ethoxylated glycerides, glycol esters, monoglycerides, polyglyceryl esters, polyhydric alcohol esters and ethers, sorbitan/sorbitol esters and ethoxylated alcohols including lanolin. The invention further relates to methods of treatment of skin diseases, more particularly acne.
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