| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: present invention relates to a method of producing physiologically active 6-(N-alkylfluorophosphonyloxy)-5,5-dialkyl-6-aza-7-substituted bicyclo[2.2.1]-heptene-2 of general formula: , where X- CH2, O; R1=CH3, i-C3H7, i-C4H9; R2=H, CH3 C2H5, i-C3H7, i-C4H9, . The disclosed method lies in obtaining the target substance by reacting difluoroanhydride of methyl-phosphonic acid with 6-(N-trimethylsilyloxy)-5,5-dialkyl-5-aza-7-substituted bicyclo[2.2.1]-heptene-2 of general formula , where X, R1 and R2 are given above, at 20-25C for 0.5-2 hours. ^ EFFECT: design of a method of obtaining novel physiologically active compounds. ^ 1 cl, 1 ex, 4 tbl |
