A biopsy system is provided including a housing, a biopsy instrument operatively associated with the housing (12), configured and dimensioned to remove a tissue sample from a patient. A firing module (16) is included that is detachably engageable with the housing (12), and operatively associated with the biopsy instrument to facilitate selective rapid advancement of at least a portion of the biopsy instrument toward a targeted location with the patient. The biopsy instrument includes a tissue receiving portion (80). The system may include an indexing assembly disposed within the housing, and configured to cooperate with the biopsy instrument to selectively orient the tissue receiving portion. The indexing assembly (588) may include a manual gearing assembly (563) configured for selective orientation of the tissue receiving portion. The system may include a linear advancement control assembly (570) disposed within the housing and configured to effect linear actuation of a tubular knife (548) member.
