| 发明名称 |
Therapeutic agents comprising pro-apoptotic proteins |
| 摘要 |
The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-inducing factor, such as granzyme B, granzyme A, or Bax. |
| 申请公布号 |
US7759091(B2) |
申请公布日期 |
2010.07.20 |
| 申请号 |
US20080040111 |
申请日期 |
2008.02.29 |
| 申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
ROSENBLUM MICHAEL G.;LIU YUYING |
| 分类号 |
C12N15/09;C12P21/06;A61K38/00;A61K38/18;A61K38/48;A61K39/395;A61K45/00;A61K47/44;A61K47/48;A61K48/00;A61P1/04;A61P3/10;A61P9/10;A61P19/02;A61P27/02;A61P35/00;A61P35/04;A61P43/00;C07H21/04;C07K14/00;C07K14/47;C07K14/475;C07K14/52;C07K14/575;C07K16/00;C07K16/18;C07K16/22;C07K16/40;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/06;C12N5/10;C12N5/24;C12N7/00;C12N9/00;C12N9/64;C12N15/12;C12P21/02 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
