发明名称 |
METHOD FOR THE ENHANCEMENT OF CHEMICAL SENSITIVITY OR RADIOSENSITIVITY OF CANCER CELLS BY INHIBITING THE EXPRESSION OF TRANSGELIN 2 |
摘要 |
PURPOSE: A method for enhancing sensitivity of cancer cells on radiation or compound is provided to enhance sensitivity of cancer cells and to promoter cancer cell apoptosis. CONSTITUTION: An anti-cancer adjuvant contains an agent of suppressing expression or activation of trangelin 2 protein having an amino acid sequence of sequence number 1. The agent of suppressing trangelin 2 protein is an antisense nucleotide of trangelin 2 gene or small interfering RNA. The cancer cells are lung cancer cells. The anti-cancer adjuvant enhances sensitivity of cancer cells on a compound or radiation. The compound is cisplatin, methyl methane-sulfonate(MMS), or hydrogen peroxide(H_2O_2).
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申请公布号 |
KR20100082125(A) |
申请公布日期 |
2010.07.16 |
申请号 |
KR20090001460 |
申请日期 |
2009.01.08 |
申请人 |
KOREA ATOMIC ENERGY RESEARCH INSTITUTE |
发明人 |
KIM, IN GYU;KIM, TAE LIM;PAIK, SANG GI;KIM, KUG CHAN;JUNG, IL LAE;KANG, SE CHAN;CHO, EUN WIE |
分类号 |
A61K31/70;A61K33/24;A61P35/00 |
主分类号 |
A61K31/70 |
代理机构 |
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主权项 |
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地址 |
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