发明名称 |
VECTOR FOR TREATMENT VACCINE FOR STABLE AND CONSTITUTIVE HIGH-EXPRESSION CERVICAL CANCER AND RECOMBINANT LACTOBACILLUS TRANSFORMED BY THE SAME |
摘要 |
The present invention relates to a surface expression vector for HPV vaccine preparation including a gene that encodes an antigen protein related to the occurrence of human papilloma virus tumors, connected with: a composite gene with repE mutation gene having the amino sequence of sequence No. 1, a promoter, a poly-gamma-glutamate synthetase complex, and a poly-gamma-glutamate synthetase complex gene. The recombinant lactobacillus of the present invention that has been transformed into a surface expression vector of the antigen protein of the human papilloma virus, and the composition using the same, may be utilized as a treatment vaccine for cervical cancer and directly applied to the cervical or vaginal area, so that it has very economical effects. |
申请公布号 |
WO2010079991(A2) |
申请公布日期 |
2010.07.15 |
申请号 |
WO2010KR00126 |
申请日期 |
2010.01.08 |
申请人 |
BIOLEADERS CORPORATION;KOOKMIN UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;SUNG, MOON-HEE;POO, HARYOUNG;LEE, IL HAN |
发明人 |
SUNG, MOON-HEE;POO, HARYOUNG;LEE, IL HAN |
分类号 |
C12N15/86;A61K39/12;C12N15/03;C12N15/37 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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